"Resistance is futile" is a catch phrase used by the Borg of the Star Trek fictional universe.

Its first use in Star Trek came in the 1990 Star Trek: The Next Generation episode "The Best of Both Worlds," written by Michael Piller. It was later used by Piller in the Star Trek: Deep Space Nine pilot episode "Emissary". It was made more popular as the tagline of the 1996 film Star Trek: First Contact by the actor Jeff Coopwood who was the "Voice of the Borg" in that film.

"Resistance is futile" has subsequently been assimilated into popular culture as a proverb and has become a cultural meme. The term is often used in the media to describe a desperate and failing struggle 'against the flow'.^[1][2]

The phrase, as spoken by Picard's Borg alter-ego Locutus, was ranked #93 in TV Land's list of "The 100 Greatest TV Quotes and Catchphrases".^[3]